Platelets and the vascular wall
EAS Academy. Koenen R. Nov 29, 2017; 202882 Topic: Arterial wall & AS
Disclosure(s): The work by Dr. Koenen was supported by research grants from: Netherlands Foundation for Scientific Research (ZonMW VIDI 016.126.358), the Landsteiner Foundation for Blood Transfusion Research (LSBR Nr. 1638) and Deutsche Forschungsgemeinschaft (SFB1123/A2). Dr. Koenen is a shareholder of Carolus Therapeutics Inc., San Diego, CA.

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The advanced course on Atherothrombosis that was held in Vienna in November 2017 provided a comprehensive overview of the basic principles of atherothrombosis as well the vascular alterations leading to it. Both clinical and basic science experts gave stimulating presentations on topics ranging from vascular inflammation to plaque vulnerability and clinical aspects of atherothrombosis. The contribution of the vessel wall and plaque composition as well as the role of all major vascular cells and humoral factors in atherothrombosis were discussed. Finally, novel concepts such as immunothrombosis, the role of the gut microbiome, as well as systemsbiology approaches in cardiovascular medicine were presented.
After the lecture the audience should have learned that:
- platelets can modulate the inflammatory response and the progression of immune diseases
- platelets carry molecular information that they can transfer to other cells
- extracellular vesicles from platelets can influence the behaviour of vascular cells and leukocytes.
1. Vajen, T., Benedikter, B. J., et al. Platelet extracellular vesicles induce a pro- inflammatory smooth muscle cell phenotype. Journal of extracellular vesicles 6 (1), 1–15, doi:10.1080/20013078.2017.1322454 (2017).
2. Vajen, T., Mause, S. F. & Koenen, R. R. Microvesicles from platelets: novel drivers of vascular inflammation. Thrombosis and Haemostasis 114 (2), 228–236, doi:10.1160/TH14-11-0962 (2015).
3. Koenen, R. R. The prowess of platelets in immunity and inflammation. Thrombosis and Haemostasis 116 (4), 605–612, doi:10.1160/TH16-04-0300 (2016).
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